妊娠期抗结核治疗。对胎儿的风险。
Antituberculous therapy in pregnancy. Risks to the fetus.
作者信息
Scheinhorn D J, Angelillo V A
出版信息
West J Med. 1977 Sep;127(3):195-8.
Abstract
A total of 1,939 reported births to mothers who received isoniazid ethambutol, rifampin and streptomycin alone or in combination, for all or part of their pregnancies, were surveyed to determine teratogenicity of these agents. There was no significant increase in birth defects with isoniazid, ethambutol and rifampin, in contrast to the use of streptomycin which was associated with mild auditory and vestibular defects. Guidelines for the treatment of active tuberculosis in pregnancy are therefore established.
摘要
共对1939名在孕期全部或部分时间单独或联合使用异烟肼、乙胺丁醇、利福平及链霉素的母亲所分娩的婴儿进行了调查，以确定这些药物的致畸性。与链霉素使用相关的轻度听觉和前庭缺陷不同，异烟肼、乙胺丁醇和利福平并未导致出生缺陷显著增加。因此制定了孕期活动性肺结核的治疗指南。
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本文引用的文献
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STREPTOMYCIN IN PREGNANCY: EFFECT ON THE FOETAL EAR.孕期使用链霉素：对胎儿耳部的影响。
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STREPTOMYCIN MEDICATION DURING PREGNANCY AND THE CHILD'S HEARING.
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ETHAMBUTOL ADMINISTRATION DURING PREGNANCY: A CASE REPORT.孕期使用乙胺丁醇：一例病例报告。
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CONGENITAL DEFECTS AMONG CHILDREN BORN TO WOMEN UNDER SUPERVISION OR TREATMENT FOR PULMONARY TUBERCULOSIS.接受肺结核监管或治疗的女性所生育子女的先天性缺陷
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Ethambutol-isoniazid versus PAS-isoniazid in original treatment of pulmonary tuberculosis.
Am Rev Respir Dis. 1967 Sep;96(3):428-38. doi: 10.1164/arrd.1967.96.3.428.
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Isoniazid therapy in relation to later occurrence of cancer in adults and in infants.异烟肼治疗与成人及婴儿后期癌症发生的关系。
Br Med J. 1967 Jun 24;2(5555):792-5. doi: 10.1136/bmj.2.5555.792.
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Prax Pneumol. 1971 May;25(5):255-62.
9
[Streptomycin therapy during pregnancy and its effect on the hearing of the offspring].
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Indian J Chest Dis. 1969 Jan;11(1):51-3.
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