Bokhman I V, Rybin E P, Maximov S I, Chkuaseli G T, Mikaia N A
Vopr Onkol. 1996;42(5):61-2.
Multiple primary tumors have been detected in 192 (5.0%) cases out of 3,812 patients with primary cervical malignancies, 100 (2.6%) cases having been traced to radiation-related origin. The peculiarities of the syndrome of radiation-induced multiple tumors of the rectum, vagina and corpus uteri, duration of their development, histological patterns, degree of cell differentiation, depth of invasion and patterns of metastasis spreading have been identified. Relative cumulative risk of secondary tumor development and causal factors have been established.
在3812例原发性宫颈癌患者中,有192例(5.0%)检测到多发原发性肿瘤,其中100例(2.6%)可追溯到与放疗相关的起源。已明确了直肠、阴道和子宫体放疗诱发多发肿瘤综合征的特点、其发展持续时间、组织学模式、细胞分化程度、浸润深度和转移扩散模式。还确定了继发性肿瘤发生的相对累积风险和因果因素。