Steinkraus V, Hein J
Hautklinik, Universitäts-Krankenhaus Eppendorf, Hamburg.
Verh Dtsch Ges Pathol. 1996;80:230-3.
Fifteen cases with suspected urticarial vasculitis which were seen during the last ten years at the Department of Dermatology in Hamburg were reviewed. The cases were reevaluated after strict formulation of criteria for vasculitis (fibrin in and around small vessels, leukocytoclasis of neutrophilic granulocytes, extravasation of erythrocytes) and discussed in the context of the international literature on urticarial vasculitis. The conclusion of our study is that urticarial vasculitis is often overdiagnosed clinically if persistent urticarial lesions occur that show some erythematous changes or a hint of hemorrhage. Furthermore, urticarial vasculitis is often overdiagnosed histopathologically because some cases of urticaria were found that presented with heavy infiltration of small vessel walls with neutrophilic granulocytes. In these cases extravasation of erythrocytes, fibrin in and around vessels and leukocytoclasis is always absent. In summary urticarial vasculitis seems to be a variation of leukocytoclastic vasculitis with less extravasation of erythrocytes and not, as frequently stated, and entity of its own.
回顾了过去十年间在汉堡皮肤科就诊的15例疑似荨麻疹性血管炎的病例。在严格制定血管炎标准(小血管内及周围的纤维蛋白、嗜中性粒细胞核破碎、红细胞外渗)后,对这些病例进行了重新评估,并结合国际上关于荨麻疹性血管炎的文献进行了讨论。我们研究的结论是,如果持续性荨麻疹皮损出现一些红斑改变或有出血迹象,临床上荨麻疹性血管炎常被过度诊断。此外,荨麻疹性血管炎在组织病理学上也常被过度诊断,因为发现一些荨麻疹病例表现为小血管壁有大量嗜中性粒细胞浸润。在这些病例中,总是不存在红细胞外渗、血管内及周围的纤维蛋白以及核破碎现象。总之,荨麻疹性血管炎似乎是白细胞破碎性血管炎的一种变体,红细胞外渗较少,并非如通常所说的是一种独立的疾病实体。