Pasquier F, Lavenu I, Lebert F, Jacob B, Steinling M, Petit H
Department of Neurology, University Hospital, Lille, France.
Dement Geriatr Cogn Disord. 1997 Mar-Apr;8(2):85-91. doi: 10.1159/000106669.
We tested the interobserver reliability of visual rating of HMPAO-SPECT imaging in 271 outpatients referred to a memory clinic, and followed over 1 year. The clinical diagnoses were Alzheimer's disease (n = 156), frontotemporal dementia (n = 47); vascular dementia (n = 21), senile dementia of Lewy body type (n = 12), anxiety/depressive disorders (n = 14) and miscellaneous memory disorders (n = 21). The interobserver agreement was good (k = 0.68). However, the heterogeneity of the patterns-independent from demographic data, age at onset and duration of the disease- and their lack of sensibility and specificity limited the contribution of SPECT for diagnostic purposes in routine practice.
我们对271名转诊至记忆门诊的门诊患者进行了HMPAO-SPECT成像视觉评分的观察者间可靠性测试，并对其进行了超过1年的随访。临床诊断包括阿尔茨海默病（n = 156）、额颞叶痴呆（n = 47）、血管性痴呆（n = 21）、路易体痴呆（n = 12）、焦虑/抑郁障碍（n = 14）和其他记忆障碍（n = 21）。观察者间一致性良好（k = 0.68）。然而，与人口统计学数据、发病年龄和病程无关的模式异质性及其缺乏敏感性和特异性，限制了SPECT在常规实践中用于诊断目的的作用。
