Lindsay D S, Butler J M, Blagburn B L
Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849-5519, USA.
Vet Parasitol. 1997 Jan;68(1-2):35-40. doi: 10.1016/s0304-4017(96)01054-0.
Neospora caninum is a major cause of abortion in dairy cattle in the United States and other countries. Abortions and neonatal mortality also occur in other ruminant species. Decoquinate is an anticoccidial that is approved for use in cattle and goats in the United States. We studied the efficacy of decoquinate against tachyzoites of N. caninum in a 5-day of treatment, cell culture flask lesion-based assay. Decoquinate killed tachyzoites at concentrations of 0.1 and 0.01 microgram ml-1. Decoquinate had little measurable effect on extracellular tachyzoites. Decoquinate acted quickly to kill intracellular stages at coccidiocidal concentrations; tachyzoites were killed within 5 min at 0.1 microgram ml-1 decoquinate.
犬新孢子虫是美国和其他国家奶牛流产的主要原因。其他反刍动物物种也会出现流产和新生仔畜死亡的情况。地克珠利是一种抗球虫药，在美国被批准用于牛和山羊。我们在一项基于细胞培养瓶损伤的5天治疗试验中研究了地克珠利对犬新孢子虫速殖子的疗效。地克珠利在浓度为0.1和0.01微克/毫升时可杀死速殖子。地克珠利对细胞外速殖子几乎没有可测量的影响。地克珠利在抗球虫浓度下能迅速杀死细胞内阶段的虫体；在0.1微克/毫升地克珠利作用下，速殖子在5分钟内被杀死。
