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转录因子与核小体：酵母中PHO5启动子的调控

Transcription factors vs nucleosomes: regulation of the PHO5 promoter in yeast.

作者信息

Svaren J, Hörz W

机构信息

Department of Pathology, Washington University School of Medicine, St Louis, MO 63110-1093, USA.

出版信息

Trends Biochem Sci. 1997 Mar;22(3):93-7. doi: 10.1016/s0968-0004(97)01001-3.

DOI:10.1016/s0968-0004(97)01001-3
PMID:9066259
Abstract

Activation of the Saccharomyces cerevisiae PHO5 gene is accompanied by the disruption of four positioned nucleosomes at the promoter. The chromatin transition requires a DNA-binding protein, Pho4, and its transactivation domain. The mechanism of nucleosome disruption and the contribution of the nucleosomes to PHO5 regulation are reviewed.

摘要

酿酒酵母PHO5基因的激活伴随着启动子处四个定位核小体的破坏。染色质转变需要一种DNA结合蛋白Pho4及其反式激活结构域。本文综述了核小体破坏的机制以及核小体对PHO5调控的作用。

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Transcription factors vs nucleosomes: regulation of the PHO5 promoter in yeast.转录因子与核小体：酵母中PHO5启动子的调控
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Histone H2A.Z regulats transcription and is partially redundant with nucleosome remodeling complexes.组蛋白H2A.Z调控转录，并且与核小体重塑复合体部分功能冗余。
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A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PHO5 promoter.核小体在体内可阻止转录因子Pho4与PHO5启动子中的关键靶位点结合。
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In vitro reconstitution of PHO5 promoter chromatin remodeling points to a role for activator-nucleosome competition in vivo.体外重建 PHO5 启动子染色质重塑表明激活子-核小体竞争在体内的作用。
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Structural and functional requirements for the chromatin transition at the PHO5 promoter in Saccharomyces cerevisiae upon PHO5 activation.酿酒酵母中PHO5激活时PHO5启动子处染色质转变的结构和功能要求。
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The transactivation domain of Pho4 is required for nucleosome disruption at the PHO5 promoter.Pho4的反式激活结构域是PHO5启动子处核小体破坏所必需的。
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Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes.由组蛋白伴侣Asf1介导的染色质解聚对于酵母PHO5和PHO8基因的转录激活至关重要。
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Activation of Saccharomyces cerevisiae HIS3 results in Gcn4p-dependent, SWI/SNF-dependent mobilization of nucleosomes over the entire gene.酿酒酵母HIS3的激活导致在整个基因上Gcn4p依赖、SWI/SNF依赖的核小体移动。
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