转录因子与核小体：酵母中PHO5启动子的调控
Transcription factors vs nucleosomes: regulation of the PHO5 promoter in yeast.
作者信息
Svaren J, Hörz W
机构信息
Department of Pathology, Washington University School of Medicine, St Louis, MO 63110-1093, USA.
出版信息
Trends Biochem Sci. 1997 Mar;22(3):93-7. doi: 10.1016/s0968-0004(97)01001-3.
PMID:9066259
Abstract
Activation of the Saccharomyces cerevisiae PHO5 gene is accompanied by the disruption of four positioned nucleosomes at the promoter. The chromatin transition requires a DNA-binding protein, Pho4, and its transactivation domain. The mechanism of nucleosome disruption and the contribution of the nucleosomes to PHO5 regulation are reviewed.
摘要
酿酒酵母PHO5基因的激活伴随着启动子处四个定位核小体的破坏。染色质转变需要一种DNA结合蛋白Pho4及其反式激活结构域。本文综述了核小体破坏的机制以及核小体对PHO5调控的作用。
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