Dolsma W V, De Vries E G, Van der Mark T W, Sleijfer D T, Willemse P H, Van Der Graaf W T, Mulder P O, Szabó B G, Mulder N H
Department of Radiation Oncology, University Hospital Groningen, The Netherlands.
Anticancer Res. 1997 Jan-Feb;17(1B):537-40.
Our aim was to study the extent of pulmonary toxicity after high-dose chemotherapy and radiotherapy in breast cancer patients. In a retrospective study the pulmonary symptoms and chest X-rays were analyzed before, during and after treatment in 17 patients, treated with loco-regional radiotherapy to the breast/chest wall and the regional lymph nodes after the completion of high-dose chemotherapy and autologous bone marrow transplantation for locally advanced breast cancer. Lung function was evaluated between 15 and 46 months after completion of the irradiation. Nine patients (53%) had pulmonary symptoms during and/or within two months from irradiation. Radiographic changes were seen in twelve patients (71%) and a decreased diffusion capacity occurred in nine patients (53%). The spirometric values (VC and FEV1) were abnormal in two patients (12%). There is a high incidence of radiation pneumonitis, although no consistent correlation between the various parameters (pulmonary symptoms, chest X-rays and lung function tests) could be found.
我们的目的是研究乳腺癌患者在接受高剂量化疗和放疗后肺部毒性的程度。在一项回顾性研究中，分析了17例局部晚期乳腺癌患者在高剂量化疗和自体骨髓移植完成后，接受乳腺/胸壁及区域淋巴结局部放疗期间及治疗前、后的肺部症状和胸部X光片。在放疗结束后15至46个月评估肺功能。9例患者（53%）在放疗期间和/或放疗后两个月内出现肺部症状。12例患者（71%）出现影像学改变，9例患者（53%）出现弥散功能下降。2例患者（12%）的肺量计值（肺活量和第1秒用力呼气量）异常。放射性肺炎的发生率很高，尽管在各项参数（肺部症状、胸部X光片和肺功能测试）之间未发现一致的相关性。
