Kristjansson A K, Eiriksdottir G, Ragnarsson G, Sigurdsson A, Gudmundsson J, Barkardottir R B, Jonasson J G, Egilsson V, Ingvarsson S
Department of Pathology, University and National Hospital of Iceland, Reykjavik, Iceland.
Anticancer Res. 1997 Jan-Feb;17(1A):93-8.
In this study 238 human primary breast cancers were analysed with 9 polymorphic microsatellite markers specific to region 7q21-q35 on chromosome 7. LOH was observed at one or more marker in 82 cases or (34%). The deletions were evenly distributed throughout the region. Patients were divided into two groups according to whether LOH was observed in their tumours or not, and tested for association with overall survival, the clinicopathological features: steroid receptor content, tumour size, node status, DNA ploidy and S-phase fraction, and LOH at other chromosomal regions. An association was found between 7q LOH and high S-phase fraction. An association was found between LOH at 7q and LOH at 1p, 3p, 9p, 13q and 17q. These results suggest the location of a putative tumour suppressor gene at chromosome 7q21-q35 that, in combination with other deletions, might enhance tumour growth.
在本研究中，运用9个定位于7号染色体7q21 - q35区域的多态性微卫星标记，对238例原发性人类乳腺癌进行了分析。在82例（34%）病例中，观察到一个或多个标记出现杂合性缺失（LOH）。这些缺失在整个区域均匀分布。根据肿瘤中是否观察到LOH，将患者分为两组，并检测其与总生存期、临床病理特征（类固醇受体含量、肿瘤大小、淋巴结状态、DNA倍体和S期分数）以及其他染色体区域的LOH之间的关联。发现7q LOH与高S期分数之间存在关联。还发现7q处的LOH与1p、3p、9p、13q和17q处的LOH之间存在关联。这些结果表明，在7号染色体7q21 - q35处可能存在一个肿瘤抑制基因，该基因与其他缺失共同作用，可能会促进肿瘤生长。
