氯肽菌素，从链霉菌属中分离出的新型抗HIV抗生素，可抑制gp120与CD4的结合。二、氯肽菌素I的结构解析
Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. II. Structure elucidation of chloropeptin I.
作者信息
Matsuzaki K, Ogino T, Sunazuka T, Tanaka H, Omura S
机构信息
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1997 Jan;50(1):66-9. doi: 10.7164/antibiotics.50.66.
PMID:9066768
Abstract
The structure of chloropeptin I, a gp120-CD4 binding inhibitor having a potent anti-HIV activity, was elucidated by 1H and 13C NMR experiments and chemical degradation. It is a peptide antibiotic consisting of six aryl amino acids residues and an alpha-oxo aryl acid some of which have chlorine atoms.
摘要
氯肽素I是一种具有高效抗HIV活性的gp120-CD4结合抑制剂，其结构通过1H和13C NMR实验以及化学降解得以阐明。它是一种肽类抗生素，由六个芳基氨基酸残基和一个α-氧代芳基酸组成，其中一些含有氯原子。
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