Department of Chemical Biology, School of Sciences, Henan Agricultural University, Zhengzhou 450002, China.
Institute of Pesticide, School of Plant Protection, Henan Agricultural University, Zhengzhou 450002, China.
Molecules. 2023 Feb 8;28(4):1647. doi: 10.3390/molecules28041647.
3,n-fused ( = 4-7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformations have received much attention in recent years. This review summarizes recent developments in the synthesis of these tricyclic indoles with palladium-catalyzed domino reactions and their applications in the total synthesis of representative natural products.
3,n-稠合（=4-7）三环吲哚是普遍存在的结构基序，嵌入在各种生物活性分子和天然产物中。因此，在过去几十年中，已经开发出许多用于合成这些骨架的催化方法。特别是，钯催化的转化近年来受到了广泛关注。本综述总结了钯催化的串联反应在这些三环吲哚合成中的最新进展及其在代表性天然产物全合成中的应用。
