Lifshitz K, O'Keeffe R T, Linn G S, Lee K L, Camp-Bruno J A, Suckow R F
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA.
Biol Psychiatry. 1997 Mar 15;41(6):657-67. doi: 10.1016/S0006-3223(96)00169-2.
Sixty-one weeks after 48 weeks of treatment with fluphenazine decanoate or placebo, 37 socially living Cebus apella monkeys were evaluated for differences in dopaminergic sensitivity by exposure to 0.75 mg/kg, i.m. of amphetamine (AMPH) (indirect agonist) and apomorphine (APOM) (direct agonist). The fluphenazine-treated animals differed (p < or = 0.05) from control animals on some hourly measures of composite behavioral variables (CBVs). Animals exposed to fluphenazine showed a greater decrease in the aggressiveness CBV and a smaller decrease in self- and environment-directed behaviors than placebo animals. CBVs for normal locomotion and directs affiliation showed no significant differences. The fluphenazine-treated group showed greater agonist induction of stereotypic behavior (p < or = 0.01), and larger decreases in prolactin response to AMPH (p < or = 0.05). Our findings indicate that following extended treatment with an antipsychotic there is increased sensitivity to dopamine, as evidenced by stereotypies and possibly hypophyseal responsiveness.
在用癸酸氟奋乃静或安慰剂治疗48周后的61周，对37只群居的僧帽猴进行评估，通过肌肉注射0.75毫克/千克的苯丙胺（AMPH）（间接激动剂）和阿扑吗啡（APOM）（直接激动剂）来检测多巴胺能敏感性的差异。在一些复合行为变量（CBV）的每小时测量指标上，接受氟奋乃静治疗的动物与对照动物存在差异（p≤0.05）。与接受安慰剂的动物相比，接受氟奋乃静治疗的动物在攻击性行为CBV上的下降幅度更大，而在自我导向和环境导向行为上的下降幅度更小。正常运动和直接社交行为的CBV没有显著差异。接受氟奋乃静治疗的组表现出更强的激动剂诱导的刻板行为（p≤0.01），并且对AMPH的催乳素反应下降幅度更大（p≤0.05）。我们的研究结果表明，长期使用抗精神病药物治疗后，对多巴胺的敏感性增加，表现为刻板行为以及可能的垂体反应性。
