Chen W J, Loh E W, Hsu Y P, Cheng A T
Division of Epidemiology and Public Health, Academia Sinica, Taipei, Taiwan.
Biol Psychiatry. 1997 Mar 15;41(6):703-9. doi: 10.1016/S0006-3223(96)00072-8.
Previous population association studies have indicated that certain alleles of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes may reduce the risk of alcoholism in Oriental populations. In this report we determined the genotypes for three genes, ADH2, ADH3, and ALDH2 among subjects with alcohol dependence (n = 159) and ethnically matched normal controls (n = 149) for the four largest aboriginal groups (Atayal, Ami, Bunun, and Paiwan) in Taiwan. The ethnicity matching used in this study was feasible because there are still few intergroup marriages between these aboriginal groups. On a group level, the rare frequencies of ALDH2*2, the inactive allele of ALDH2, among these aborigines may account partially for their vulnerability to alcohol use disorders. On an individual level, however, the genotypes controlling alcohol metabolism did not account for intragroup differences in vulnerability to alcoholism except in the case of ADH2 for the Ami ethnic group.
以往的人群关联研究表明，酒精脱氢酶（ADH）和乙醛脱氢酶（ALDH）基因的某些等位基因可能会降低东方人群患酒精中毒的风险。在本报告中，我们确定了台湾四大原住民群体（泰雅族、阿美族、布农族和排湾族）中酒精依赖患者（n = 159）和种族匹配的正常对照者（n = 149）的ADH2、ADH3和ALDH2这三个基因的基因型。本研究中使用的种族匹配是可行的，因为这些原住民群体之间的族际通婚仍然很少。在群体层面上，这些原住民中ALDH2的无活性等位基因ALDH2*2的罕见频率可能部分解释了他们易患酒精使用障碍的原因。然而，在个体层面上，除了阿美族的ADH2情况外，控制酒精代谢的基因型并不能解释群体内部对酒精中毒易感性的差异。
