Cosentino A M
St. Mary's Medical Center, San Francisco, CA 94117-1079, USA.
Compr Ther. 1997 Jan;23(1):67-72.
Carefully document smoking history and other environmental exposures such as may occur in the work place. Also seek possible "triggers" such as household pets, ASA NSAIDs, and Beta Blockers. Laboratory evaluation should include a chest x-ray, ECG and Spirometry. If FEV1, sec less than 1 liter obtain ABGs. Treatment can be initiated with ipratroprium and prn use of Beta agonists. Theophyline may be useful. Corticosteroids may be effective in approximately 20% of subjects with stable COPD (nonasthmatic) and should be tried if symptom relief unsatisfactory and strongly urged before initiation of chronic O2 therapy. The role of inhaled steroids in COPD has not been adequately studied. Chronic O2 therapy in appropriate subjects may prolong life. Antibiotics are commonly prescribed for acute exacerbations of COPD, but without good supporting data. Corticosteroids, however, for acute exacerbations of COPD have been shown to be effective.
仔细记录吸烟史以及其他可能在工作场所发生的环境暴露情况。同时寻找可能的“触发因素”,如家养宠物、阿司匹林、非甾体抗炎药和β受体阻滞剂。实验室评估应包括胸部X光、心电图和肺功能测定。如果第一秒用力呼气容积(FEV1)少于1升,则进行动脉血气分析(ABGs)。治疗可从使用异丙托溴铵开始,并按需使用β受体激动剂。茶碱可能有用。皮质类固醇对约20%的稳定型慢性阻塞性肺疾病(非哮喘型)患者可能有效,如果症状缓解不令人满意,在开始长期氧疗之前应尝试使用,并强烈推荐使用。吸入性类固醇在慢性阻塞性肺疾病中的作用尚未得到充分研究。对合适的患者进行长期氧疗可能会延长生命。抗生素常用于慢性阻塞性肺疾病急性加重期,但缺乏有力的支持数据。然而,皮质类固醇已被证明对慢性阻塞性肺疾病急性加重期有效。