Fábrega E, Figols J, Dueñas C, Crespo J, Casafont F, Sanchez-Antolín G, de las Heras G, Amado J A, Pons-Romero F
Gastroenterology and Hepatology Unit, University Hospital Marques de Valdecilla, Faculty of Medicine, Santander, Spain.
Clin Transplant. 1997 Feb;11(1):25-8.
Endothelin-1 is a vasoconstrictor peptide released by the vascular endothelium by various chemical and mechanical factors. Cellular rejection is one of the most common complications following orthotopic liver transplantation, endotheliitis being its most specific and consistent histological feature. To assess the role of endothelin in cellular hepatic rejection, we studied 21 cirrhotic patients undergoing elective liver transplantation. These patients were divided in two groups: Group I comprised 10 patients without cellular rejection, and Group II comprised 11 patients with cellular rejection. Endothelin was measured on day 7 after transplantation, on the day of liver biopsy, and after treatment for rejection. We found a significant increase in the plasma endothelin levels in the early postoperative period in the patients with moderate or severe cellular rejection compared with the non-rejection group. It remained significantly elevated until the clinical diagnosis of rejection was made. This value returned to baseline with successful treatment. So, the monitorization of this peptide may be of help in the diagnosis of rejection, its severity, and the evaluation of its resolution.
内皮素-1是一种血管收缩肽，可由血管内皮在各种化学和机械因素作用下释放。细胞排斥反应是原位肝移植后最常见的并发症之一，内皮细胞炎是其最具特异性和一致性的组织学特征。为了评估内皮素在细胞性肝排斥反应中的作用，我们研究了21例接受择期肝移植的肝硬化患者。这些患者被分为两组：第一组包括10例无细胞排斥反应的患者，第二组包括11例有细胞排斥反应的患者。在移植后第7天、肝活检当天以及抗排斥治疗后检测内皮素水平。我们发现，与无排斥反应组相比，中度或重度细胞排斥反应患者术后早期血浆内皮素水平显著升高。在临床诊断出排斥反应之前，该水平一直显著升高。随着治疗成功，该值恢复到基线水平。因此，监测这种肽可能有助于排斥反应的诊断、评估其严重程度以及判断其缓解情况。
