Inomata Y, Tanaka K, Egawa H, Uemoto S, Kiuchi T, Satomura K, Uyama S, Okajima H
Department of Transplantation Immunology, Faculty of Medicine, Kyoto University, Japan.
Clin Transplant. 1997 Feb;11(1):56-9.
In living-related liver transplantation, a portion of the whole liver, usually the left lateral segment or the left lobe, is harvested for use as the graft liver. A relatively small graft may twist around the hepatic venous anastomosis, causing outflow blockage. After an initial experience of such a complication in the early post-transplantation period in one case, we began to apply a tissue expander to obliterate the dead space left after emplacement of a relatively small graft. Commercially available tissue expanders, ordinary employed in plastic surgery, were used for five pediatric recipients (6-14 yr old) whose ratio of graft weight to recipient body weight ranged from 0.74 to 1.72. The expander, filled with 240-350 ml saline, was put into the space to the right of the graft. Aspiration of the expander content was started after the 5th-7th postoperative day (POD), at a rate of 50 ml of fluid a day. The expanders were taken out on the 11th-14th POD after complete removal of the content. Complications observed in the five cases were right shoulder pain (5/5), fluid collection after removal of the expander(2/5), chylous ascites (1/5), and one instance of bile leakage. All the complications were successfully managed and controlled conservatively. There was no outflow obstruction detected by Doppler ultrasonography before or after removal of the expander. This is a simple and safe method for preventing the early onset of outflow block after partial liver transplantation.
在活体肝移植中,通常切取整个肝脏的一部分,即左外叶或左叶,作为移植肝。相对较小的移植肝可能会围绕肝静脉吻合口扭转,导致流出道梗阻。在1例患者移植术后早期出现这种并发症的初步经验后,我们开始应用组织扩张器来消除放置相对较小的移植肝后留下的死腔。将整形外科常用的市售组织扩张器应用于5例儿科受者(6 - 14岁),其移植肝重量与受者体重之比为0.74至1.72。将充满240 - 350毫升生理盐水的扩张器放入移植肝右侧的空间。术后第5 - 7天开始抽出扩张器内的液体,每天抽出50毫升。在完全抽出扩张器内容物后,于术后第11 - 14天取出扩张器。5例患者观察到的并发症有右肩痛(5/5)、取出扩张器后积液(2/5)、乳糜腹水(1/5)和1例胆漏。所有并发症均通过保守治疗成功处理和控制。在取出扩张器前后,多普勒超声均未检测到流出道梗阻。这是一种预防部分肝移植后早期流出道梗阻的简单安全方法。