肝硬化病程中的血浆游离前列腺素E2和6-酮-前列腺素F1α

Plasma iPGE2 and i6-keto PGF1 alpha in the course of liver cirrhosis.

作者信息

Flisiak R, Prokopowicz D

机构信息

Department of Infectious Diseases, University Medical School, Bialystok, Poland.

出版信息

Prostaglandins. 1997 Jan;53(1):11-20. doi: 10.1016/s0090-6980(96)00137-2.

DOI:10.1016/s0090-6980(96)00137-2

PMID:9068063

Abstract

Plasma iPGE2 and i6-keto PGF1 alpha were measured with an EIA assay in twenty patients with alcohol-related liver cirrhosis (ALC group) and 13 patients with hepatitis B virus as an etiologic factor of liver cirrhosis (HLC group). Significant increase of both prostanoids was observed irrespectively of the etiology of liver cirrhosis. Their levels increased depending on the degree of liver insufficiency with the highest values in patients classified as Child-Pugh C class. A significant, positive correlation with Child-Pugh score was found regarding PGE2 (r = 0.657; p < 0.001) as well as 6-keto PGF1 alpha (r = 0.736; p < 0.001). Correlation (r = 0.789; p < 0.001) was also observed between levels of both prostaglandins. In conclusion we have shown that plasma iPGE2 and i6-keto PGF1 alpha arise simultaneously with the degree of liver insufficiency, that can be a result of activation of non-parenchymal liver cells accompanying hepatic fibrosis.

摘要

采用酶免疫分析（EIA）法检测了20例酒精性肝硬化患者（酒精性肝硬化组）和13例以乙型肝炎病毒作为肝硬化病因的患者（乙肝肝硬化组）的血浆中白细胞介素-前列腺素E2（iPGE2）和6-酮-前列腺素F1α（i6-keto PGF1α）水平。无论肝硬化病因如何，均观察到这两种前列腺素显著升高。它们的水平根据肝功能不全的程度而升高，在Child-Pugh C级患者中达到最高值。发现PGE2（r = 0.657；p < 0.001）以及6-酮-前列腺素F1α（r = 0.736；p < 0.001）与Child-Pugh评分呈显著正相关。两种前列腺素水平之间也观察到相关性（r = 0.789；p < 0.001）。总之，我们已经表明，血浆iPGE2和i6-酮-前列腺素F1α与肝功能不全的程度同时出现，这可能是肝纤维化伴随的非实质肝细胞激活的结果。