Markman M, Peereboom D M
Department of Hematology/Oncology, Cleveland Clinic Foundation, OH 44195, USA.
Cleve Clin J Med. 1997 Mar;64(3):155-63. doi: 10.3949/ccjm.64.3.155.
Although screening of natural products remains the major method of discovering new anticancer drugs, newer techniques of rational drug design, computer-aided drug design, and combinatorial synthesis promise to broaden the scope of compounds available for screening. Recent changes in Food and Drug Administration rules allow for accelerated approval of drugs for treating cancer and other life-threatening illnesses, although the three-phase process of clinical trials remains largely unchanged.
尽管天然产物筛选仍是发现新型抗癌药物的主要方法，但合理药物设计、计算机辅助药物设计及组合合成等新技术有望拓宽可供筛选的化合物范围。美国食品药品监督管理局规则的近期变化允许加速批准用于治疗癌症及其他危及生命疾病的药物，尽管临床试验的三个阶段大体上仍保持不变。
