Agnew-Heard K A, Sánchez Peña M, Shamsi S A, Warner I M
Department of Chemistry, Louisiana State University, Baton Rouge 70803, USA.
Anal Chem. 1997 Mar 1;69(5):958-64. doi: 10.1021/ac960778w.
The polymerized surfactant poly(sodium N-undecylenyl amino L-valinate) [poly(L-SUV)] has been used in micellar electrokinetic capillary chromatography for the chiral separation of various acidic and basic drugs, as well as neutral compounds. Under the conditions studied, poly(L-SUV) was shown to be a very versatile anionic chiral selector in the pH range of 5.6-11. The micelle was used for the enantioseparation of coumarinic anticoagulant drugs with various buffers under moderately acidic conditions. Neutral and alkaline buffer conditions were used to successfully separate the neutral atropisomers (+/-)-1,1'-bi-2-naphthol, (+/-)-1,1'-binaphthyl-2,2'-diamine, and Tröger's base. Chiral separation of the cationic paveroline drugs, laudanosine, norlaudanosoline, and laudanosoline, was influenced by pH and the use of coated capillaries. The acquired data focused on optimizing the migration times, capacity and separation factors, and electrophoretic mobilities of the various racemic mixtures.
聚合表面活性剂聚（N-十一碳烯基-L-缬氨酸钠）[聚（L-SUV）]已用于胶束电动毛细管色谱法，用于各种酸性和碱性药物以及中性化合物的手性分离。在所研究的条件下，聚（L-SUV）在5.6-11的pH范围内被证明是一种非常通用的阴离子手性选择剂。该胶束用于在中等酸性条件下用各种缓冲液对香豆素类抗凝药物进行对映体分离。中性和碱性缓冲条件用于成功分离中性轴手性异构体（+/-）-1,1'-联-2-萘酚、（+/-）-1,1'-联萘基-2,2'-二胺和特罗格碱。阳离子帕维罗林药物劳丹诺辛、去甲劳丹诺辛和劳丹索林的手性分离受pH值和涂层毛细管的使用影响。所获得的数据集中于优化各种外消旋混合物的迁移时间、容量和分离因子以及电泳迁移率。
