无转座酶的转座：细菌中的一种自发突变
Transposition without transposase: a spontaneous mutation in bacteria.
作者信息
Rappleye C A, Roth J R
机构信息
Department of Biology, University of Utah 84112, USA.
出版信息
J Bacteriol. 1997 Mar;179(6):2047-52. doi: 10.1128/jb.179.6.2047-2052.1997.
Abstract
Transposition mutations are typically associated with the activities of transposable elements such as transposons and insertion sequences, whose mobility is dependent upon transposase enzymes that catalyze exchanges between element ends and target sites. We describe a single transposition event in which a block of donor sequence is inserted at a target site without the involvement of any known transposase or the ends of any known transposable element. We propose that this is a new type of spontaneous mutation which may be difficult to detect in standard mutant hunts but may be of evolutionary importance.
摘要
转座突变通常与转座子和插入序列等转座元件的活性相关，这些元件的移动性取决于转座酶，转座酶催化元件末端与靶位点之间的交换。我们描述了一个单一的转座事件，其中一段供体序列插入到一个靶位点，而没有任何已知转座酶或任何已知转座元件末端的参与。我们提出这是一种新型的自发突变，在标准的突变筛选中可能难以检测到，但可能具有进化重要性。
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