托吡卡胺的散瞳作用及其在阿尔茨海默病中的诊断应用。

The mydriatic effect of tropicamide and its diagnostic use in Alzheimer's disease.

作者信息

Reitner A, Baumgartner I, Thuile C, Baradaran Dilmaghani R, Ergun E, Kaminski S, Lukas J, Dal Bianco P

机构信息

Department of Ophthalmology, University of Vienna, Austria.

出版信息

Vision Res. 1997 Jan;37(1):165-8. doi: 10.1016/s0042-6989(96)00119-8.

DOI:10.1016/s0042-6989(96)00119-8

PMID:9068838

Abstract

The mydriatic effect of topically administered tropicamide was investigated as a possible diagnostic indicator for Alzheimer's disease. Although an initial series seemed to show a correlation between hypersensitivity to tropicamide and intellectual impairment, subsequent testing showed a greater inter- and intra-individual variation than that between the normal group and the group of patients with intellectual impairment. This procedure seems, therefore, to lack sufficient specificity to be useful for such a diagnostic purpose.

摘要

局部应用托吡卡胺的散瞳效应被作为阿尔茨海默病的一种可能诊断指标进行了研究。尽管最初的一系列研究似乎显示对托吡卡胺的超敏反应与智力损害之间存在关联，但后续测试显示个体间和个体内的差异比正常组与智力损害患者组之间的差异更大。因此，该方法似乎缺乏足够的特异性，无法用于此类诊断目的。