Usui S, Ishihara A, Kamiyama Y, Ishii H
Department of Information and Computer Sciences, Toyohashi University of Technology, Japan.
Vision Res. 1996 Dec;36(24):4069-76. doi: 10.1016/s0042-6989(96)00179-4.
We propose an ionic current model of bipolar cells based on the published experimental data. Five types of ionic currents identified in bipolar cell bodies, Ih, IKv, IA, ICa and IK(Ca) were described by a mathematical formulation similar to the Hodgkin and Huxley (Journal of Physiology, 117, 500-544, 1952) equations. The model parameters were estimated from the voltage clamp data. In simulation, we demonstrate that the present model reproduces not only the voltage clamp responses but also the current clamp responses of the bipolar cells. As a result, the model provides a better understanding of the functional role of the ionic currents in bipolar cells in generating the electrical responses.
我们基于已发表的实验数据提出了一种双极细胞的离子电流模型。通过类似于霍奇金和赫胥黎（《生理学杂志》，117卷，500 - 544页，1952年）方程的数学公式来描述在双极细胞体中识别出的五种离子电流，即Ih、IKv、IA、ICa和IK(Ca)。模型参数是根据电压钳数据估计得出的。在模拟中，我们证明当前模型不仅能重现双极细胞的电压钳响应，还能重现其电流钳响应。因此，该模型有助于更好地理解离子电流在双极细胞产生电响应过程中的功能作用。
