依贝地平对血管平滑肌细胞动脉粥样硬化发展、细胞生长及癌基因表达的作用。
Action of elgodipine on atherosclerosis development, cell growth, and oncogene expression in vascular smooth muscle cells.
作者信息
Del Rio M, Ruiz E, Tejerina T
机构信息
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
出版信息
Gen Pharmacol. 1997 Mar;28(3):463-8. doi: 10.1016/s0306-3623(96)00067-5.
PMID:9068992
Abstract
- Elgodipine (ELG) had no significant effect on aortic content of cholesterol, plasma cholesterol, or triglycerides concentrations in cholesterol-fed rabbits. However, ELG administration produced a dose-dependent and significant reduction of calcium content of the aorta. 2. In vitro studies showed that ELG was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression of the transcription factors c-fos and c-jun.
摘要
- 依戈地平（ELG）对喂饲胆固醇的家兔的主动脉胆固醇含量、血浆胆固醇或甘油三酯浓度没有显著影响。然而，给予依戈地平可使主动脉钙含量呈剂量依赖性显著降低。2. 体外研究表明，依戈地平能够通过一种独立于转录因子c-fos和c-jun表达的机制抑制血管平滑肌增殖。
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