T细胞抗原受体信号转导

T cell antigen receptor signal transduction.

作者信息

Qian D, Weiss A

机构信息

Howard Hughes Medical Institute, Department of Medicine, U426, University of California, San Francisco, CA 94143, USA.

出版信息

Curr Opin Cell Biol. 1997 Apr;9(2):205-12. doi: 10.1016/s0955-0674(97)80064-6.

DOI:10.1016/s0955-0674(97)80064-6

PMID:9069257

Abstract

The T cell antigen receptor (TCR) initiates signal transduction by activating multiple cytoplasmic protein tyrosine kinases (PTKs). Considerable progress in the field of TCR signal transduction has been made in three areas recently: first, in understanding the structure and function of the PTK ZAP-70; second, in the elucidation of the function of the substrates and pathways downstream of the PTKs; and third, in the identification of molecules that negatively regulate TCR signalling.

摘要

T细胞抗原受体（TCR）通过激活多种细胞质蛋白酪氨酸激酶（PTK）来启动信号转导。最近，TCR信号转导领域在三个方面取得了显著进展：第一，在理解PTK ZAP-70的结构和功能方面；第二，在阐明PTK下游底物和信号通路的功能方面；第三，在鉴定负向调节TCR信号传导的分子方面。