Jan L Y, Jan Y N
Howard Hughes Medical Institute, Department of Physiology, Biochemistry, University of California San, Francisco, CA 94143-0724, USA.
Curr Opin Cell Biol. 1997 Apr;9(2):155-60. doi: 10.1016/s0955-0674(97)80057-9.
Recent advances in the study of receptor-regulated ion channels include the cloning of the genes encoding three types of potassium channel that are favorite targets of receptors for transmitters and hormones. Studies of these channels have also provided a strong indication that G-protein betagamma subunits may gate ion channels via direct protein-protein interactions. Similarities between channel regulation by natriuretic peptides and channel regulation by secreted peptide products of the Alzheimer's beta-amyloid precursor protein offer hints for the existence of a receptor for the latter. There are also other novel examples of channel regulation in excitable and nonexcitable cells, including liver cells and blood cells.
受体调控离子通道研究的最新进展包括克隆了编码三种钾通道的基因，这三种钾通道是神经递质和激素受体的热门靶点。对这些通道的研究还有力地表明，G蛋白βγ亚基可能通过直接的蛋白质-蛋白质相互作用来控制离子通道。利钠肽对通道的调节与阿尔茨海默病β-淀粉样前体蛋白的分泌肽产物对通道的调节之间的相似性，为后者存在受体提供了线索。在可兴奋和不可兴奋细胞（包括肝细胞和血细胞）中，也存在其他通道调节的新例子。
