Pani S P, Srividya A, Krishnamoorthy K, Das P K, Dhanda V
Vector Control Research Centre, Pondicherry, India.
Natl Med J India. 1997 Jan-Feb;10(1):19-22.
New strategies are emerging for control of filariasis in terms of chemotherapy and vector control. Field application of these tools requires mapping and prioritization of filaria-endemic areas and quantification of the infection/ disease burden. Available procedures are time-consuming, costly and have poor sensitivity. Therefore, rapid assessment procedures need to be developed to assess the disease burden as well as monitor and evaluate control programmes.
Data collected on different variables from 25 areas in India and elsewhere were used. The relationship between prevalence of human infection and vector infection rate was analysed quantitatively. Due to lack of independent samples, only qualitative analysis was carried out between other epidemiological variables such as infection and disease prevalence in relation to age, gender and manifestation.
There was a significant positive correlation between vector infection rate and infection prevalence in humans, suggesting that vector infection can be used as an indicator in the rapid assessment of infection prevalence. Scatter plots showed that community screening may be limited to the age group of 11-30 years for infection prevalence and 20-50 years for disease prevalence. Further, clinical surveys may be limited to only hydrocele prevalence which may be sufficient to predict the total disease. This can also be used as an alternative method by the community itself for delimiting endemic areas.
Vector infection rate may be used as an indicator for rapid assessment of human infection. Alternatively, blood smear examination could be limited to the age group of 11-30 years. For a rapid survey of the diseases, males in the age group of 20-50 years could be examined only for hydrocele.
在化疗和病媒控制方面，控制丝虫病的新策略正在不断涌现。这些工具的现场应用需要对丝虫病流行地区进行绘图和优先级排序，并对感染/疾病负担进行量化。现有的程序既耗时又昂贵，而且灵敏度较低。因此，需要开发快速评估程序来评估疾病负担，并监测和评估控制项目。
使用从印度和其他地区的25个地区收集的关于不同变量的数据。对人类感染率和病媒感染率之间的关系进行了定量分析。由于缺乏独立样本，仅对其他流行病学变量（如感染和疾病患病率与年龄、性别和表现的关系）进行了定性分析。
病媒感染率与人类感染患病率之间存在显著的正相关，这表明病媒感染可作为快速评估感染患病率的指标。散点图显示，社区筛查在感染患病率方面可能仅限于11至30岁的年龄组，在疾病患病率方面可能仅限于20至50岁的年龄组。此外，临床调查可能仅限于鞘膜积液患病率，这可能足以预测总疾病情况。这也可被社区自身用作划定流行地区的替代方法。
病媒感染率可作为快速评估人类感染的指标。或者，血液涂片检查可仅限于11至30岁的年龄组。对于疾病的快速调查，仅对20至50岁年龄组的男性进行鞘膜积液检查即可。
