Pharmacokinetics in drug therapy III: Clindamycin dosage regimens for treatment of chronic osteomyelitis.

A patient case which illustrates the application of pharmacokinetic principles to the dosing of clindamycin is presented. Based on calculations of a pharmacist, a patient wtih chronic osteomylitis was successfully treated at home with oral clindamycin 300 mg every four hours. The calculations showed that adequate blood and bone levels of the drug would be reached.