Kuratsune H, Watanabe Y, Yamaguti K, Jacobsson G, Takahashi M, Machii T, Onoe H, Onoe K, Matsumura K, Valind S, Kitani T, Långström B
Subfemtomole Biorecognition Project, Japan Science and Technology Corporation, Osaka, Japan.
Biochem Biophys Res Commun. 1997 Feb 13;231(2):488-93. doi: 10.1006/bbrc.1996.5919.
The brain uptake of acetylcarnitine was investigated in rhesus monkeys using different position labeled acetyl-L-carnitine and related molecules with 11C by positron emission tomography. The uptake values of radio-labeled acetylcarnitine into the brain were quite different depending on the labeling positions of 11C. That is, the uptake values of L-[methyl-11C]carnitine and acetyl-L-[methyl-11C]carnitine were almost the same and extremely low, while the uptake of [1-11C]-acetyl-L-carnitine was slightly higher. The uptake value of [2-11C]acetyl-L-carnitine was by far the highest among the 11C-labeled acetyl-L-carnitine and L-carnitine. The uptake of [2-11C]acetyl-L-carnitine into the brain was suppressed by the intravenous administration of glucose. These results suggest that endogenous serum acetyl-L-carnitine has some roles on conveying an acetyl moiety into the brain especially under an energy crisis, and that an unknown metabolic pathway of [2-11C]acetyl moiety might be rather active in the brain.
利用不同位置标记的乙酰 -L-肉碱及相关分子与含碳 -11（¹¹C）的化合物，通过正电子发射断层扫描技术，在恒河猴身上研究了乙酰肉碱的脑摄取情况。¹¹C标记位置不同，放射性标记的乙酰肉碱在脑中的摄取值差异很大。也就是说，L-[甲基 -¹¹C]肉碱和乙酰 -L-[甲基 -¹¹C]肉碱的摄取值几乎相同且极低，而[1-¹¹C]-乙酰 -L-肉碱的摄取值略高。在¹¹C标记的乙酰 -L-肉碱和L-肉碱中，[2-¹¹C]乙酰 -L-肉碱的摄取值是最高的。静脉注射葡萄糖会抑制[2-¹¹C]乙酰 -L-肉碱进入大脑。这些结果表明，内源性血清乙酰 -L-肉碱在将乙酰基部分转运至大脑中发挥着一定作用，尤其是在能量危机情况下，并且[2-¹¹C]乙酰基部分未知的代谢途径在大脑中可能相当活跃。
