Nef与PAK：毒力因子与细胞协同因子
Nef and PAK: virulence factor and cellular accomplice.
作者信息
Trono D, Wang J K
机构信息
Salk Institute for Biological Studies, La Jolla, CA 92037-1099, USA.
出版信息
Chem Biol. 1997 Jan;4(1):13-5. doi: 10.1016/s1074-5521(97)90232-5.
PMID:9070423
Abstract
The Nef protein is important in HIV replication and in AIDS pathogenesis. The finding that Nef activates a member of the PAK family of protein kinases provides new insights into the mechanisms of action of this critical virulence factor.
摘要
Nef蛋白在HIV复制和艾滋病发病机制中起着重要作用。Nef激活蛋白激酶PAK家族中的一个成员这一发现，为这种关键毒力因子的作用机制提供了新的见解。
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