Dixon C E, Ma X, Marion D W
Department of Neurosurgery, University of Pittsburgh Medical Center, PA 15260, USA.
Brain Res. 1997 Feb 21;749(1):127-30. doi: 10.1016/s0006-8993(96)01310-8.
Neocortical acetylcholine (ACh) release was examined in awake, freely-moving rats at 14 days following lateral controlled cortical impact. Extracellular ACh was measured prior to and after an intraperitoneal administration of scopolamine, which evokes ACh release by blocking autoreceptors. At 14 days post-injury there was a significant reduction in scopolamine-evoked ACh release. The data suggest that neocortical cholinergic neurotransmission is chronically compromised, and may contribute to post-traumatic memory deficits.
在可控性大脑皮层撞击损伤14天后，对清醒自由活动的大鼠的新皮层乙酰胆碱（ACh）释放情况进行了检测。在腹腔注射东莨菪碱前后测量细胞外ACh水平，东莨菪碱通过阻断自身受体来诱发ACh释放。损伤后14天，东莨菪碱诱发的ACh释放显著减少。数据表明，新皮层胆碱能神经传递长期受损，这可能导致创伤后记忆缺陷。
