Upregulation of actin gene expression in cells expressing exogenous beta-amyloid precursor protein.
作者信息
Ramakrishna N, Smedman M, Ramakrishna V, Gillam B
机构信息
NYS Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA.
出版信息
Biochem Biophys Res Commun. 1997 Feb 24;231(3):615-8. doi: 10.1006/bbrc.1997.6137.
PMID:9070857
Abstract
We investigated the effects of beta-amyloid peptide precursor (APP) overexpression upon the levels of other mRNAs. Using quantitative slot-blot hybridization and immunoblot analysis we observed that enhanced levels of APP elevated the levels of beta-actin and beta-actin mRNA. Our results also suggest that the cytoplasmic domain of APP is crucial for the elevation in beta-actin gene expression.
摘要
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