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Upregulation of actin gene expression in cells expressing exogenous beta-amyloid precursor protein.

作者信息

Ramakrishna N, Smedman M, Ramakrishna V, Gillam B

机构信息

NYS Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA.

出版信息

Biochem Biophys Res Commun. 1997 Feb 24;231(3):615-8. doi: 10.1006/bbrc.1997.6137.

DOI:10.1006/bbrc.1997.6137
PMID:9070857
Abstract

We investigated the effects of beta-amyloid peptide precursor (APP) overexpression upon the levels of other mRNAs. Using quantitative slot-blot hybridization and immunoblot analysis we observed that enhanced levels of APP elevated the levels of beta-actin and beta-actin mRNA. Our results also suggest that the cytoplasmic domain of APP is crucial for the elevation in beta-actin gene expression.

摘要

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