小鼠13号染色体上Lyst基因周围的物理图谱和遗传图谱。
The physical and genetic map surrounding the Lyst gene on mouse chromosome 13.
作者信息
Misumi D J, Nagle D L, McGrail S H, Dussault B J, Smutko J S, Chen H, Charlat O, Duyk G M, Ebeling C, Baldini L, Carlson G A, Moore K J
机构信息
Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA.
出版信息
Genomics. 1997 Feb 15;40(1):147-50. doi: 10.1006/geno.1996.4549.
During the recent cloning of the mouse Lyst gene we developed both a high-resolution genetic map and a complete YAC and BAC contig of the Lyst critical region on mouse Chromosome 13. We also report the mapping of the human homologue of the mouse Lyst gene (LYST) to 1q43. These data are consistent with LYST being the gene for the human Chediak-Higashi Syndrome and strengthen the synteny relationship between MMU13 and human 1q43.
在最近克隆小鼠Lyst基因的过程中，我们绘制了一张高分辨率的遗传图谱，并构建了小鼠13号染色体上Lyst关键区域完整的酵母人工染色体（YAC）和细菌人工染色体（BAC）重叠群。我们还报告了小鼠Lyst基因（LYST）的人类同源基因定位于1q43。这些数据与LYST是人类切-东综合征（Chediak-Higashi Syndrome）的致病基因这一观点相符，并加强了小鼠13号染色体与人类1q43之间的同线性关系。
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