Takeuchi Y, Kikusui T, Kizumi O, Ohnishi H, Mori Y
Laboratory of Veterinary Ethology, University of Tokyo, Japan.
J Vet Med Sci. 1997 Feb;59(2):125-7. doi: 10.1292/jvms.59.125.
To establish an adequate experimental model for the study of immuno-neuroendocrine mechanisms underlying the behavioral changes during the acute infection, temporal relationship of various physiological responses to endotoxin administration was examined in ovariectomized goats. Immediately after intravenous injection of 200 ng/kg of lipopolysaccharide, there were an abrupt decrease of white blood cell number and a gradual increase of rectal temperature, which were followed by elevation of plasma levels of adrenocorticotropic hormone, cortisol, glucose, free fatty acids, and then later by an increase of heart rate. The results suggest that the endotoxin administration would evoke a stereotyped cascade of, febrile, neuroendocrine and metabolic as well as autonomic response to the activation of immune systems in the ruminant species.
为建立一个合适的实验模型来研究急性感染期间行为变化背后的免疫-神经内分泌机制，在去卵巢山羊中检测了各种生理反应与内毒素给药的时间关系。静脉注射200 ng/kg脂多糖后，白细胞数量立即急剧下降，直肠温度逐渐升高，随后促肾上腺皮质激素、皮质醇、葡萄糖、游离脂肪酸的血浆水平升高，随后心率增加。结果表明，内毒素给药会引发反刍动物物种免疫系统激活后典型的发热、神经内分泌、代谢以及自主神经反应级联。
