Jongwutiwes S, Putaporntip C
Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 1996 Dec;79 Suppl 1:S33-9.
The merozoite surface protein 2 (MSP2) of Plasmodium falciparum was a malaria vaccine candidate. The gene encoding MSP2 of a Thai isolate was amplified by polymerase chain reaction followed by subcloning into a phagemid vector and sequencing. Sequence alignment with other previously published sequences revealed that the MSP2 allele in this isolate belonged to FC27 allelic family. The central variable sequence of the MSP2 allele in this study was related to an allele from Indonesia. The flanking sequences of the variable region were highly conserved.
恶性疟原虫的裂殖子表面蛋白2（MSP2）是一种疟疾疫苗候选物。通过聚合酶链反应扩增泰国分离株编码MSP2的基因，随后亚克隆到噬菌粒载体中并进行测序。与其他先前发表的序列进行序列比对显示，该分离株中的MSP2等位基因属于FC27等位基因家族。本研究中MSP2等位基因的中央可变序列与来自印度尼西亚的一个等位基因相关。可变区的侧翼序列高度保守。
