Yoshikawa T, Ochiai R, Kaneko T, Takeda J, Fukushima K, Tsukada H, Seki C, Kakiuchi T
Department of Anesthesiology, School of Medicine, Keio University, Tokyo.
Masui. 1997 Feb;46(2):237-43.
The effects of sevoflurane on cerebral metabolism and hemodynamics were studied in rhesus monkeys. Cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMR O2) as well as their regional changes were measured by means of positron emission tomography technique. After the measurement of regional CBFs and CMR O2s at 1.5% sevoflurane as control, the measurement was repeated at 3.0% sevoflurane and at the same sevoflurane concentration with the infusion of angiotensin II to restore mean arterial pressure. Regional CBFs and CMR O2s were compared among three different conditions. At 3.0% sevoflurane, regional CBFs increased significantly in response to the increase in the mean arterial pressure, suggesting the inhibition of autoregulation of CBF. However, regional CBF/CMR O2 ratio was not significantly different among the cerebral regions with each condition. It could be concluded that CBF during sevoflurane anesthesia up to 3.0% might become dependent on the cerebral perfusion pressure and the changes in regional CBFs varied among the regions. On the other hand, the ratio of oxygen consumption and delivery was well maintained throughout the brain regions.
在恒河猴中研究了七氟醚对脑代谢和血流动力学的影响。采用正电子发射断层扫描技术测量脑血流量（CBF）、脑氧代谢率（CMR O2）及其区域变化。以1.5%七氟醚作为对照测量区域CBF和CMR O2后，在3.0%七氟醚以及在相同七氟醚浓度下输注血管紧张素II以恢复平均动脉压时重复测量。比较三种不同情况下的区域CBF和CMR O2。在3.0%七氟醚时，区域CBF随着平均动脉压的升高而显著增加，提示CBF自身调节受到抑制。然而，每种情况下各脑区的区域CBF/CMR O2比值无显著差异。可以得出结论，高达3.0%七氟醚麻醉期间的CBF可能依赖于脑灌注压，且区域CBF的变化在各区域有所不同。另一方面，全脑各区域的氧消耗与输送比值保持良好。
