Nomori H, Horio H
Department of Surgery, Saiseikai Central Hospital, Tokyo, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1997 Feb;45(2):146-8.
Twenty-six cases with lung cancer diagnosed by open-lung (n = 11) or thoracoscopic (n = 15) biopsy were analyzed. Mean tumor size was 19 mm. Biopsies were conducted due to the appearance of a nodular shadow determined by the retrospective X-p films in 13 cases, nodular shadow enlargement in 9, the positive suspicion of malignancy X-p findings without retrospective films in 3, and nodular shadow enlargement after medication of anti-tuberculosis drugs in one. Histology was adenocarcinoma in 18 cases, squamous cell carcinoma in 4, large cell carcinoma in 3, and adenosquamous cell carcinoma in one. The tumor stage was T1N0M0 in 14 cases, T1N0M0 in 3, T1N2M0 in 3, and unknown N factor because of lung wedge resection in 6 cases. Motality due to tumor recurrence was T1N2M0 in 3 cases and T1N1M0 in one. The remaining 22 cases survived without tumor recurrence. In short, small pulmonary nodules newly appearing or becoming with enlarged or found by retrospective X-p films should be conducted positively in thoracoscopic biopsy because of the high possibility of malignancy. Even if the tumor is small, lobectomy with lymph node dissection should be done, because of the very likely lymph node metastasis.
分析了26例经开胸(n = 11)或胸腔镜(n = 15)活检确诊为肺癌的病例。肿瘤平均大小为19毫米。活检的进行原因如下:13例因回顾性胸部X线片发现结节状阴影,9例因结节状阴影增大,3例无回顾性胸片但X线检查高度怀疑为恶性,1例因抗结核药物治疗后结节状阴影增大。组织学类型为腺癌18例,鳞状细胞癌4例,大细胞癌3例,腺鳞癌1例。肿瘤分期为T1N0M0 14例,T1N0M0 3例,T1N2M0 3例,6例因肺楔形切除无法确定N因素。肿瘤复发导致死亡的情况为T1N2M0 3例,T1N1M0 1例。其余22例无肿瘤复发存活。总之,新出现或增大的肺小结节或回顾性胸部X线片发现的结节,由于恶性可能性高,应积极进行胸腔镜活检。即使肿瘤较小,也应行肺叶切除加淋巴结清扫,因为很可能发生淋巴结转移。