Nomura M, Fujimura M, Matsuda T, Kitagawa M
Second Department of Internal Medicine, Koseiren Takaoka Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Jan;35(1):72-6.
A 75-year-old man had for many years taken the commercially sold medicine PABRON-S whenever he caught a cold. He caught a cold and took the drug six days before admission. When PABRON-S was not available, he took PABRON-GOLD and experienced dyspnea the next day. A roentgenogram at another hospital revealed bilateral diffuse lung shadows. He was referred to our hospital. A thoracic CT scan showed bilateral interstitial shadows. Bronchoalveolar lavage fluid contained inflammatory cells including neutrophils and lymphocytes. Examination of a transbronchial lung biopsy specimen showed infiltration of mononuclear cells into the thick alveolar wall and interstitum. A drug lymphocyte stimulation test with PABRON-GOLD was positive. Based on these findings, we believe that this patient had drug-induced pneumonitis caused by PABRON-GOLD. He was treated with a steroid hormone and his symptoms resolved immediately, the abnormal roentgenographic shadows remained longer.
一名75岁男性多年来每当感冒时都会服用市售药物帕布龙 - S。他在入院前六天感冒并服用了该药物。当没有帕布龙 - S时，他服用了帕布龙 - 金，第二天出现呼吸困难。另一家医院的X光片显示双侧弥漫性肺部阴影。他被转诊至我院。胸部CT扫描显示双侧间质阴影。支气管肺泡灌洗液中含有包括中性粒细胞和淋巴细胞在内的炎性细胞。经支气管肺活检标本检查显示单核细胞浸润至增厚的肺泡壁和间质。用帕布龙 - 金进行的药物淋巴细胞刺激试验呈阳性。基于这些发现，我们认为该患者患有由帕布龙 - 金引起的药物性肺炎。他接受了类固醇激素治疗，症状立即缓解，但异常的影像学阴影持续时间更长。
