Kopecká H
Unité de Virologie Moléculaire, URA 1966 CNRS, Institut Pasteur, Paris, France.
Epidemiol Mikrobiol Imunol. 1996 Dec;45(4):135-42.
Molecular biological methods offer new approaches to the study of RNA viruses. On the example of enteroviruses we tried to give an account, of recent progress in the knowledge and understanding of these important human pathogens. Firstly concerning their structural and genomic organisation; secondly as regards understanding of their pathology and pathogenicity; thirdly the impact of such methods on rapid, sensitive and specific diagnosis, treatment, on epidemiology and finally on evolution and classification of the large picornavirus family where the enterovirus genus belongs. We believe that molecular biology will elucidate still unknown features of enteroviruses, which are not yet correctly evaluated human pathogens.
分子生物学方法为研究RNA病毒提供了新途径。以肠道病毒为例,我们试图阐述对这些重要人类病原体的认识和理解方面的最新进展。首先是关于它们的结构和基因组组织;其次是对其病理学和致病性的理解;第三是这些方法对快速、灵敏且特异的诊断、治疗、流行病学的影响,最后是对肠道病毒所属的微小RNA病毒科的进化和分类的影响。我们相信分子生物学将阐明肠道病毒仍不为人知的特征,而这些病毒是尚未得到正确评估的人类病原体。