轴突导向：揭示了网蛋白受体。

Axon guidance: netrin receptors are revealed.

作者信息

Guthrie S

机构信息

Department of Developmental Neurobiology, UMDS, Guy's Hospital, London SE1 9RT, UK.

出版信息

Curr Biol. 1997 Jan 1;7(1):R6-9. doi: 10.1016/s0960-9822(06)00007-8.

DOI:10.1016/s0960-9822(06)00007-8

PMID:9072174

Abstract

Netrins are molecules that guide growing axons and that are strikingly similar in sequence and in function in flies, nematodes and vertebrates. Now, members of a family of netrin receptors have been identified in all three animal groups and shown to have crucial, conserved roles in axon navigation.

摘要

Netrins是引导轴突生长的分子，在果蝇、线虫和脊椎动物中，其序列和功能都极为相似。如今，在这三类动物群体中均已鉴定出Netrin受体家族的成员，并且这些受体在轴突导向中发挥着关键的、保守的作用。