[The pathogenetic role of a natural inhibiting factor in acute and chronic liver diseases of viral etiology].

Pathogenetic role was studied of NIF in patients with viral hepatitides (VH) A, B and C, as well as chronic hepatitis such as persisting (ChPH) and active (ChAH) HBsAg+. It has been ascertained that under evolving chronic pathology of the liver in terminating acute VH, NIF tends to rise, which observation is compatible with clinical and laboratory signs of chronization of the pathological process in the liver. In ChAH and hepatocirrhosis (HC) during the phase of exacerbation major proportions of patient populations demonstrate lowering of NIF levels as evidenced by low values for the antibody inhibition reaction. Compensated HC is is associated with an elevated index of inhibition (II), which observation is accompanied by improvement of parameters associated with the immune response. Pathogenetic significance of NIF per mit adopting differentiated therapy with immunocorrecting drugs taking into account the level of the parameter in question.