一氧化氮合酶抑制剂NG-单甲基-L-精氨酸、NG-硝基-L-精氨酸和NG-硝基-L-精氨酸甲酯以及一氧化氮供体硝酸甘油对清醒状态下的自发性高血压大鼠（SHRSP）和京都Wistar大鼠（WKY）的血流动力学影响。

Haemodynamic effects of NO-synthase inhibitors, NG-monomethyl-L-arginine, NG-nitro-L-arginine and NG-nitro-L-arginine methyl ester, and NO-donor, glyceryl trinitrate, in conscious SHRSP and WKY.

Higashino H, Simeonova K, Lambev I, Suzuki A

Department of Pharmacology, Kinki University School of Medicine, Osaka-Sayama, Japan.

Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S151-3. doi: 10.1111/j.1440-1681.1995.tb02860.x.

Abstract

The experiments were carried out by an ordinary and a microsphere method in order to clarify the effects of three nitric oxide-synthase inhibitors and -donor on the circulating system between SHRSP and WKY. 2. Intravenous administration of each compound possessing the nitric acid-synthase inhibiting action markedly elevated the systolic blood pressure both in SHRSP and WKY, but more prominently in the former. 3. The hypotensive and tachycardic responses to glyceryl trinitrate were more enhanced after treatment with NG-nitro-L-arginine and NG-nitro-L-arginine methyl ester but not with NG-monomethyl-L-arginine compared with the non-treated one. 4. All peripheral organs except the brain decreased their regional blood flow after administration of NG-nitro-L-arginine, indicating a crucial involvement of nitric oxide in the peripheral circulation. 5. It was suggested that the nitric oxide system worked more sensitively and actively in SHRSP than in WKY in order to maintain the peripheral blood flow and systemic blood pressure.

摘要

为阐明三种一氧化氮合酶抑制剂和供体对SHRSP和WKY循环系统的影响，采用常规方法和微球法进行了实验。2. 静脉注射具有硝酸合酶抑制作用的每种化合物，均使SHRSP和WKY的收缩压显著升高，但在前者中更为明显。3. 与未处理组相比，用NG-硝基-L-精氨酸和NG-硝基-L-精氨酸甲酯处理后，对硝酸甘油的降压和心动过速反应增强，而用NG-单甲基-L-精氨酸处理则无此现象。4. 除脑外，所有外周器官在给予NG-硝基-L-精氨酸后其局部血流量均减少，表明一氧化氮在外周循环中起关键作用。5. 提示一氧化氮系统在SHRSP中比在WKY中更敏感、更活跃地发挥作用，以维持外周血流量和全身血压。