重组人促红细胞生成素对慢性肾衰竭自发性高血压大鼠血压及肾功能的影响。

Effects of recombinant human erythropoietin on blood pressure and renal function in SHR with chronic renal failure.

Kohzuki M, Yasujima M, Kanazawa M, Yoshida K, Sato T, Abe K

Section of Internal Medicine and Disability Prevention, Tohoku University Graduate School, Sendai, Japan.

Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S165-6. doi: 10.1111/j.1440-1681.1995.tb02865.x.

Abstract

The effects of chronic administration of erythropoietin (EPO) on blood pressure and renal function in rats with ablation of renal mass were assessed. 2. Spontaneously hypertensive rat were subjected to 5/6 nephrectomy (5/6Nx). Four weeks after the operation, the rats were randomly allocated to vehicle, EPO 20IU/kg i.p., or EPO 100 IU/kg i.p. (both given twice a week) for 4 weeks. 3. Marked anaemia was noted in SHR-5/6Nx. EPO caused a significant increase in haematocrit at a high dose but not at a low dose. A dose dependent relationship was noted in the EPO-induced rise in the systolic blood pressure. 4. EPO dose-dependently increased urinary protein excretion. It also increased blood urea nitrogen and serum creatinine levels. 5. These results suggest that EPO ameliorates anaemia and severely accelerates renal failure in SHR-5/6Nx. They also suggest that anaemia can be a haemodynamically favorable adaptation to chronic renal disease and that its correction may have adverse renal haemodynamic and structural consequences.

摘要

评估了长期给予促红细胞生成素（EPO）对肾大部切除大鼠血压和肾功能的影响。2. 将自发性高血压大鼠进行5/6肾切除术（5/6Nx）。术后4周，将大鼠随机分为三组，分别给予溶剂对照、腹腔注射20IU/kg EPO或腹腔注射100IU/kg EPO（均每周给药两次），持续4周。3. 在SHR-5/6Nx大鼠中观察到明显贫血。高剂量EPO可显著提高血细胞比容，但低剂量则无此作用。EPO引起的收缩压升高呈剂量依赖性。4. EPO剂量依赖性增加尿蛋白排泄。它还增加了血尿素氮和血清肌酐水平。5. 这些结果表明，EPO可改善SHR-5/6Nx大鼠的贫血，但会严重加速肾衰竭。它们还表明，贫血可能是对慢性肾病的一种血液动力学上有利的适应性反应，纠正贫血可能会对肾脏血液动力学和结构产生不良后果。