高血压大鼠主动脉中血管钠尿肽受体的基因表达

Gene expression of vascular natriuretic peptide receptor in the aorta of hypertensive rats.

Yoshimoto T, Naruse M, Naruse K, Fujimaki Y, Tanabe A, Muraki T, Hagiwara H, Hirose S, Demura H

Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical College, Shinjuku-ku, Japan.

Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S175-6. doi: 10.1111/j.1440-1681.1995.tb02870.x.

Abstract

To elucidate the pathophysiologic role of vascular natriuretic peptide (NP) receptor in hypertension, we determined NP-A and NP-B receptor mRNA levels by means of ribonuclease protection assay in aorta of three types of hypertensive rats. 2. The NP-A receptor mRNA level was higher in stroke-prone spontaneously hypertensive rats (SHR-SP/Izm) and deoxycorticosterone acetate-salt hypertensive rats than that in their respective control rats. On the contrary, the NP-A receptor mRNA level was lower in NG-nitro-L-arginine-methyl ester (L-NAME)-induced hypertensive rats compared with that in the control. 3. The NP-B receptor mRNA level did not show any significant change in all three hypertensive rats compared with their respective controls. 4. The present study suggests that high blood pressure is not the major factor regulating the NP receptor gene expression and also that the receptor subtype is independently regulated from each other.

摘要

为了阐明血管利钠肽（NP）受体在高血压中的病理生理作用，我们通过核糖核酸酶保护分析，测定了三种高血压大鼠主动脉中NP-A和NP-B受体的mRNA水平。2. 易卒中型自发性高血压大鼠（SHR-SP/Izm）和醋酸脱氧皮质酮盐性高血压大鼠的NP-A受体mRNA水平高于各自的对照大鼠。相反，与对照相比，NG-硝基-L-精氨酸甲酯（L-NAME）诱导的高血压大鼠的NP-A受体mRNA水平较低。3. 与各自的对照相比，所有三种高血压大鼠的NP-B受体mRNA水平均未显示出任何显著变化。4. 本研究表明，高血压不是调节NP受体基因表达的主要因素，而且受体亚型彼此独立调节。