高胆固醇饮食喂养的Dahl盐敏感大鼠和自发性高血压大鼠主动脉中不同的胆固醇沉积。

Different cholesterol deposition in aorta of Dahl salt-sensitive rats and spontaneously hypertensive rats fed a high-cholesterol diet.

Yamaguchi Y, Kitagawa S, Kwon Y, Shinozuka K, Kunitomo M

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.

Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S249-50. doi: 10.1111/j.1440-1681.1995.tb02903.x.

Abstract

We compared the serum and aortic lipid levels in spontaneously hypertensive rats (SHR) and Dahl salt-sensitive rats (DSR) fed a high-cholesterol (HC) diet. 2. In SHR fed the HC diet, the serum cholesterol level significantly increased, but no aortic cholesterol deposition was observed. 3. The serum cholesterol level in DSR fed the HC diet markedly increased compared to that in DSR fed the basal diet, and this change was greater with the diet containing 8% NaCl than 0.4% NaCl. A significant increase in the content of aortic cholesterol, notably cholesteryl ester, was observed in only DSR fed the HC diet containing 8% NaCl. 4. These results suggest that the combination of hypercholesterolaemia with salt-induced hypertension acts as a greater risk factor for atherosclerosis than that with genetic hypertension.

摘要

我们比较了喂食高胆固醇（HC）饮食的自发性高血压大鼠（SHR）和Dahl盐敏感大鼠（DSR）的血清和主动脉脂质水平。2. 在喂食HC饮食的SHR中，血清胆固醇水平显著升高，但未观察到主动脉胆固醇沉积。3. 与喂食基础饮食的DSR相比，喂食HC饮食的DSR血清胆固醇水平显著升高，且含8%氯化钠饮食组的这种变化比含0.4%氯化钠饮食组更大。仅在喂食含8%氯化钠HC饮食的DSR中观察到主动脉胆固醇含量显著增加，尤其是胆固醇酯。4. 这些结果表明，高胆固醇血症与盐诱导的高血压相结合比与遗传性高血压相结合是动脉粥样硬化更大的危险因素。