颈动脉窦中的压力感受器有助于正常血压大鼠的动脉压力感受器反射。

Baroreceptors in the carotid sinus contribute to arterial baroreceptor reflexes in normotensive rats.

Ohta H, Talman W T

Laboratory of Neurobiology, Department of Neurology, University of Iowa and Veterans Affairs Medical Centre, Iowa City, USA.

Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S62-3. doi: 10.1111/j.1440-1681.1995.tb02971.x.

Abstract

Baroreceptor reflex influences on renal sympathetic nerve activity (RSNA) were estimated with non-linear regression analysis (sigmoidal curve fitting) before and after transection of carotid sinus nerves (CSN) and aortic depressor nerves (ADN) in rats. 2. Transection of ADN reduced the gain of the reflex to 42% of basal levels with increases in arterial pressure (MAP) and RSNA. Subsequent transection of CSN eliminated the remaining sigmoidal correlation between MAP and RSNA without further changes in resting MAP and RSNA. 3. By comparison, the transection of CSN reduced the gain of the reflex to 53% of basal levels without affecting other variables. Additional transection of both ADN eliminated the remaining sigmoidal correlation between MAP and RSNA with further increases in resting MAP and RSNA. 4. These results indicate that carotid sinus baroreceptors exist in rats. They contribute to baroreceptor-mediated reflex changes in RSNA as do aortic baroreceptors, although the working range of MAP may increase with transection of the latter.

摘要

在大鼠切断颈动脉窦神经（CSN）和主动脉减压神经（ADN）之前和之后，采用非线性回归分析（S形曲线拟合）评估压力感受器反射对肾交感神经活动（RSNA）的影响。2. 切断ADN后，随着动脉血压（MAP）和RSNA升高，反射增益降至基础水平的42%。随后切断CSN消除了MAP与RSNA之间剩余的S形相关性，而静息MAP和RSNA无进一步变化。3. 相比之下，切断CSN使反射增益降至基础水平的53%，而不影响其他变量。额外切断双侧ADN消除了MAP与RSNA之间剩余的S形相关性，同时静息MAP和RSNA进一步升高。4. 这些结果表明，大鼠存在颈动脉窦压力感受器。它们与主动脉压力感受器一样，对压力感受器介导的RSNA反射变化有贡献，尽管切断后者可能会增加MAP的工作范围。