易卒中型自发性高血压大鼠腔静脉中的去甲肾上腺素能神经支配过度

Noradrenergic hyperinnervation in the caval vein of stroke-prone spontaneously hypertensive rats.

Tabei R, Kondo M, Terada M, Miyazaki T, Watanabe Y, Shimizu D, Yamamoto I

Department of Pathology, Ehime University School of Medicine, Shitsukawa, Shigenobu, Onsen-gun, Japan.

Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S73-4. doi: 10.1111/j.1440-1681.1995.tb02976.x.

Abstract

The distribution of fluorescent noradrenergic (NA) nerve fibres in the caval vein, which originate from the coeliac ganglion, was examined by glyoxylic acid method in stroke-prone spontaneously hypertensive rats (SHRSP) aged 10, 30, 60, 90 and 180 days. The results were compared with those in age-matched normotensive Wistar Kyoto (WKY) rats. 2. The distribution pattern of NA nerve fibres in the caval vein in both strains changed from a meshwork pattern at 10 days of age to a wavelike line arrangement after 30 days of age. 3. The densities of NA fibres of the caval veins in SHRSP were significantly higher (P < 0.01, Student's t-test, 6 d.f.) than those of WKY at all ages examined. The difference in NA fibre density between SHRSP and WKY showed double peaks at 10 and 90 days of age. 4. The present study suggests that hyperinnervation of the caval vein based on the hyperfunction of the coeliac ganglion is an important factor in the development of hypertension and also may participate in increasing cardiac output because the heart of SHR causes marked hypertrophy from 90 days of age.

摘要

采用乙醛酸法，对10日龄、30日龄、60日龄、90日龄和180日龄的易卒中型自发性高血压大鼠（SHRSP）腹腔神经节发出的荧光去甲肾上腺素能（NA）神经纤维在腔静脉中的分布进行了研究。并将结果与年龄匹配的正常血压Wistar Kyoto（WKY）大鼠进行比较。2. 两种品系大鼠腔静脉中NA神经纤维的分布模式在10日龄时为网状，30日龄后变为波浪状排列。3. 在所有检测年龄，SHRSP腔静脉中NA纤维的密度均显著高于WKY（P < 0.01，Student氏t检验，自由度为6）。SHRSP和WKY之间NA纤维密度的差异在10日龄和90日龄时出现双峰。4. 本研究表明，基于腹腔神经节功能亢进的腔静脉去甲肾上腺素能神经纤维过度支配是高血压发生发展的重要因素，并且可能参与心输出量增加，因为SHRSP大鼠的心脏从90日龄起出现明显肥大。