Kut'ko I I, Frolov V M, Pustovoĭ Iu G, Rachkauskas G S, Pavlenko V V
Zh Nevrol Psikhiatr Im S S Korsakova. 1996;96(6):32-4.
It was established in the course of 185 schizophrenic patients' examination that intensification of lipid peroxidation (LP) took place in relapses of the disease. It was manifested either in increase of blood serum levels of both malonic dialdehyde and diene conjugates, or in decrease of erythrocytes' resistance to LP mediated hemolysis. Alterations in indices of either spontaneous or induced chemoluminescence were revealed too. LP indices were lower by the end of the treatment in hospital, but remained significantly higher than normal values. Application of antioxidants in combined treatment of schizophrenic patients promoted decrease of LP activity as well as improvement in mental state of patients. LP activity was high in the remission too. Determination of LP indices may have prognostic importance.
在对185例精神分裂症患者的检查过程中发现，在疾病复发时脂质过氧化（LP）加剧。这表现为血清中丙二醛和二烯结合物水平升高，或红细胞对LP介导的溶血抵抗力降低。同时也发现了自发或诱导化学发光指标的变化。住院治疗结束时LP指标有所降低，但仍显著高于正常值。在精神分裂症患者的联合治疗中应用抗氧化剂可促进LP活性降低以及患者精神状态改善。在缓解期LP活性也较高。测定LP指标可能具有预后意义。
