Iarema N I
Lik Sprava. 1992 Jun(6):101-3.
Changes of lipid peroxidation products and activity of the antioxidant system during corinfar and anaprilin treatment were studied in 36 patients with hypertensive disease (stage II). A decrease of the content of malondialdehyde and dien conjugates was revealed in the blood of these patients after a course of treatment with these agents. Simultaneously, the antioxidant protection of the blood increased: the concentration of reduced glutathione increased, the activity of glutathione peroxidase rose. The changes of oxidated glutathione were not clear. It is suggested that such character of the effect of corinfar and anaprilin on the processes of lipid peroxidation is the result of a direct effect on lipid peroxidation products and also compensatory activation of enzymatic reactions of restoration of natural cellular antioxidants as well as enzymatic system directly utilizing lipoperoxides.
对36例高血压病（Ⅱ期）患者在心肌梗死和心得安治疗期间脂质过氧化产物的变化及抗氧化系统活性进行了研究。这些患者经这些药物治疗一个疗程后，血液中丙二醛和二烯共轭物含量降低。同时，血液的抗氧化保护作用增强：还原型谷胱甘肽浓度升高，谷胱甘肽过氧化物酶活性增强。氧化型谷胱甘肽的变化不明显。提示心肌梗死和心得安对脂质过氧化过程的这种作用特点是对脂质过氧化产物的直接作用以及天然细胞抗氧化剂恢复的酶促反应和直接利用脂过氧化物的酶系统的代偿性激活的结果。
