肌醇1,4,5-三磷酸受体在哺乳动物嗅觉组织中的表达

Inositol 1,4,5-trisphosphate receptor expression in mammalian olfactory tissue.

作者信息

Smutzer G, Zimmerman J E, Hahn C G, Ruscheinsky D D, Rodríguez A, Han L Y, Arnold S E

机构信息

Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

出版信息

Brain Res Mol Brain Res. 1997 Mar;44(2):347-54. doi: 10.1016/s0169-328x(96)00282-3.

DOI:10.1016/s0169-328x(96)00282-3

PMID:9073177

Abstract

Two cDNAs encoding inositol 1,4,5-trisphosphate (IP3) receptors were amplified from rat olfactory tissue, and both exhibited 100% sequence identity to the short (Segment II - ) variant of type I IP3 receptor. Type III IP3 receptor was also expressed in olfactory tissue. The distribution of IP3 receptors included the olfactory epithelium, lamina propria, and glandular tissue. These results demonstrate the co-expression of multiple IP3 receptor subtypes in olfactory cells, and suggest multiple functions for IP3 receptors in this tissue.

摘要

从大鼠嗅觉组织中扩增出两个编码肌醇1,4,5 - 三磷酸（IP3）受体的cDNA，二者均与I型IP3受体的短（II段 - ）变体表现出100%的序列同一性。III型IP3受体也在嗅觉组织中表达。IP3受体的分布包括嗅觉上皮、固有层和腺组织。这些结果证明了嗅觉细胞中多种IP3受体亚型的共表达，并提示了IP3受体在该组织中的多种功能。