Matsui M, Kuroda Y
Department of Internal Medicine, Saga Medical School, Saga City, Japan.
Clin Immunol Immunopathol. 1997 Mar;82(3):203-6. doi: 10.1006/clin.1996.4311.
The immunological status of the central nervous systems of 19 patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) was distinct from that of 6 asymptomatic HTLV-I carriers. Cross-sectional analysis of the time course of disease-related abnormalities in the cerebrospinal fluid (CSF) showed that activated B cell function was a feature in relatively early HAM/TSP patients in whom duration of the disease was less than 5 to 6 years. During this period many patients experienced notable neurological deterioration. By contrast, an increase in CD8+CD11a+ cytotoxic T lymphocytes along with elevated beta 2-microglobulin levels in the CSF was a consistent finding in early as well as late patients with more than a 10-year history of the illness. In light of the generally progressive course of this disorder, the mode of immunity related to the pathogenesis of HAM/TSP may be different according to the stages of the disease.
19例人类嗜T淋巴细胞病毒I型相关脊髓病/热带痉挛性截瘫（HAM/TSP）患者中枢神经系统的免疫状态与6例无症状人类嗜T淋巴细胞病毒I型携带者不同。对脑脊液（CSF）中疾病相关异常的时间进程进行横断面分析显示，活化B细胞功能是疾病持续时间小于5至6年的相对早期HAM/TSP患者的一个特征。在此期间，许多患者出现明显的神经功能恶化。相比之下，在病程超过10年的早期和晚期患者中，脑脊液中CD8 + CD11a + 细胞毒性T淋巴细胞增加以及β2-微球蛋白水平升高是一致的发现。鉴于该疾病通常呈进行性病程，与HAM/TSP发病机制相关的免疫模式可能因疾病阶段而异。
