Liu X D, Thiele D J
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109-0606, USA.
Methods. 1997 Mar;11(3):289-99. doi: 10.1006/meth.1996.0423.
Metals and oxygen are chemically linked in biological systems. Metals and oxygen play important roles in enzymatic reactions, metabolism, and signal transduction; however, metals and oxygen react to form highly toxic oxygen-derived free radical species. In this review we focus on the use of yeast cells, as unicellular eukaryotic model systems, to conduct studies aimed at understanding fundamental mechanisms for the sensation and protective responses to toxic metals and oxygen-derived radicals via the activation of yeast metallothionein gene expression.
在生物系统中，金属与氧通过化学方式相联系。金属和氧在酶促反应、新陈代谢及信号转导过程中发挥着重要作用；然而，金属与氧发生反应会形成剧毒的氧衍生自由基。在本综述中，我们重点关注利用酵母细胞这种单细胞真核模型系统开展研究，旨在通过激活酵母金属硫蛋白基因表达来理解对有毒金属和氧衍生自由基的感知及保护反应的基本机制。
